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During the fetal stage, a number of so-called cell programs run that are vital to the development of the fetus. In a study published in Cell Reports, researchers from Lund Stem Cell Center at Lund University demonstrate that one of these fetal programs appears to protect against acute myeloid leukaemia (AML). “We have used an experimental mouse model that always results in this type of leukaemia.

https://www.stemcellcenter.lu.se/article/new-insights-fetal-development-may-protect-against-leukaemia - 2025-12-01

Hani Alsafadi defended his Ph.D. thesis on the 13th of February, 2023. With a longstanding interest in biomedical research and a passion for better understanding one of the least regenerative organs in the body, the lung, he has spent the past four years helping to uncover some of the mechanisms that may drive a lung disease currently without a cure, idiopathic pulmonary fibrosis. In this intervie

https://www.stemcellcenter.lu.se/article/exploring-role-yap-and-taz-lung-epithelium-phd-interview-hani-alsafadi - 2025-12-01

​​​​​​​Did you know that about 70% of rare diseases begin in childhood? How about that 1 in 5 cancers are considered a rare disease? Or that nearly three-quarters of all rare diseases are genetic diseases? With more than 6,000 rare diseases known to impact the lives of an estimated 300 million people around the world – rare diseases are all too common. Limited knowledge of these diseases often res

https://www.stemcellcenter.lu.se/article/shining-spotlight-rare-disease-research - 2025-12-01

On 13th of February, a transplant of stem cell-derived nerve cells was administered to a person with Parkinson’s at Skåne University Hospital, Sweden. The product has been developed by Lund Stem Cell Center researchers at Lund University and it is now being tested in patients for the first time. The transplantation product is generated from embryonic stem cells and functions to replace the dopamin

https://www.stemcellcenter.lu.se/article/first-patient-receives-milestone-stem-cell-based-transplant-parkinsons-disease - 2025-12-01

On 03 March 2023, Jenny Mattsson defended her Ph.D. thesis. With the goal to broaden the availability of antibody-based drugs for patients with cancer and other diseases, she has spent the past several years working to develop new methods that can be used to identify new antibodies and antibody targets. In this interview, we learn more about her research, how she has simultaneously juggled doing a

https://www.stemcellcenter.lu.se/article/new-methods-phenotypic-antibody-discovery-phd-interview-jenny-mattsson - 2025-12-01

Have you ever wondered what it takes to grow a brain in a petri dish or how scientists use viruses to fight genetic diseases? These are just some of the fascinating topics explored on UniStem Day 2023 at Lund Stem Cell Center in Sweden. On 10 March 2023, more than 220 high school students from across Sweden's southern Skåne region arrived at Lund Stem Cell Center at Lund University for a day of le

https://www.stemcellcenter.lu.se/article/inspiring-tomorrows-scientists - 2025-12-01

There is a large carton of chicken eggs on the bench in Sofie Mohlin's laboratory. They have been delivered during the morning and soon they will be placed in the 37-degree heat of the incubator so that the embryo can develop. Already 42 hours after fertilization, researchers can begin their experiments to study how neuroblastoma develops. Sofie Mohlin is an Associate Professor in Molecular Physio

https://www.stemcellcenter.lu.se/article/eggs-can-help-us-understand-neuroblastoma - 2025-12-01

Researchers at Lund Stem Cell Center and Lund University's Faculty of Medicine have determined a novel mechanism linking the metabolism of ribonucleic acids, RNA, to the development of leukemia in myelodysplastic syndrome patients, MDS. In a study published in the Molecular Cell journal, they explain what makes hematopoietic stem cells acquire malignant traits in cancer. RNA splicing is a major ne

https://www.stemcellcenter.lu.se/article/what-makes-blood-stem-cells-transform-regulation-rna-splicing-may-be-answer - 2025-12-01

For two decades, researchers at Lund University's strategic research area, Lund Stem Cell Center, have focused on developing and refining stem cell research to improve human health. Now that the 20th anniversary is approaching, it is time to reflect on the progress made and the possibilities that researchers see for stem cell research in the future. Stem cells can make any inventor green with envy

https://www.stemcellcenter.lu.se/article/vision-reality-20-years-cutting-edge-research-lund-stem-cell-center - 2025-12-01

Researchers from Lund Stem Cell Center are coming together with colleagues across Lund University to shape the future of healthcare. A new University-wide seed funding initiative seeking to support emerging research topics that benefit society will see interdisciplinary teams of neuroscience, medicine, and biotechnology researchers attempt to develop new, innovative, patient-specific disease model

https://www.stemcellcenter.lu.se/article/interdisciplinary-teams-lund-university-unite-develop-patient-tailored-disease-models - 2025-12-01

A recent study conducted by researchers at Lund University's Lund Stem Cell Center, and published in the Journal of Biological Chemistry, has unraveled the intricate inner workings of UM171—a molecule known for its ability to support blood stem cells. These findings not only highlight UM171's potential as a therapeutic solution for various diseases, including cancer, but also provide new insights

https://www.stemcellcenter.lu.se/article/decoding-inner-workings-blood-stem-cell-boosting-molecule - 2025-12-01

Lund Stem Cell Center researchers have published a new study that reveals the role of astrocytes in the development of frontotemporal dementia (FTD). Their findings, now in the journal Brain Communications, provide valuable insights into the cellular mechanisms of the disease and open up new possibilities for developing early diagnostics and potential interventions for patients with FTD and other

https://www.stemcellcenter.lu.se/article/new-study-reveals-astrocytes-role-frontotemporal-dementia - 2025-12-01

Fredrik Nilsson successfully defended his Ph.D. thesis on May 10, 2023. For the last four years, Fredrik has explored the use of patient-specific cells in cell replacement therapy for Parkinson's disease to identify strategies to safeguard these transplanted cells from disease-related degeneration. In this interview, he tells us about his findings, their potential implications for future therapies

https://www.stemcellcenter.lu.se/article/investigating-cell-replacement-therapy-parkinsons-disease-phd-interview-fredrik-nilsson - 2025-12-01

Lund Stem Cell Center recently hosted its Image Competition for 2023, providing a glimpse into the diverse world of stem cell science through the lens of art. The competition showcased the dedication, creativity, and scientific excellence that continue to drive our pursuit of knowledge in stem cell research. Researchers from all disciplines and experience levels at Lund Stem Cell Center participat

https://www.stemcellcenter.lu.se/article/stem-cell-science-through-lens-art - 2025-12-01

New research is underway at Lund University, led by Dr. Vivien Horvath, a postdoctoral researcher at Lund Stem Cell Center. Supported by a new grant from the Collaborative Center for X-Linked Dystonia-Parkinsonism (XDP), Vivien aims to improve our understanding of XDP, a rare neurodegenerative disorder caused by the recent insertion of a transposable element. Transposable elements, also known as '

https://www.stemcellcenter.lu.se/article/exploring-role-jumping-genes-x-linked-dystonia-parkinsonism - 2025-12-01

Mohamed Eldeeb defended his Ph.D. thesis on June 9, 2023. With a passion for scientific discovery with clinical impact, Mohamed has dedicated the last four years to unraveling the mysteries as to why some children develop pediatric leukemia and others don’t. His research shed light on the mechanisms that prevent and suppress leukemia initiation, paving the way for more effective and targeted treat

https://www.stemcellcenter.lu.se/article/mechanisms-initiation-and-suppression-pediatric-leukemia-phd-interview-mohamed-eldeeb - 2025-12-01

Lund Stem Cell Center welcomes the Targeted Therapies in Leukemia Research Group, led by molecular biologist Marcus Järås, as its newest member. With a strong background in translational research and a focus on developing innovative therapies, the group brings extensive expertise and a unique perspective to our stem cell science community at Lund University. Marcus Järås, a former student of the L

https://www.stemcellcenter.lu.se/article/targeted-therapies-leukemia-research-group-joins-lund-stem-cell-center - 2025-12-01

Lund University is establishing a university-wide development center for advanced therapies, LU-ATMP. It is an effort to move medical research with the potential for new groundbreaking therapies to reach patient groups where traditional medicines are not enough. "We want to contribute to the vision of Sweden becoming a world leader in the development and availability of advanced therapies," says E

https://www.stemcellcenter.lu.se/article/new-atmp-center-lund-university - 2025-12-01

Patricia Gerdes, a postdoctoral researcher specializing in transposable elements and their impact on the human genome, has been awarded a postdoctoral fellowship from the Marie Skłodowska-Curie Actions (MSCA) program. The grant will support a research project which focuses on understanding the role of transposable elements in human brain evolution, shedding light on healthy and disordered brain fu

https://www.stemcellcenter.lu.se/article/cracking-code-human-brain-evolution-patricia-gerdes-awarded-msca-fellowship - 2025-12-01

As certain tumor cells are able to conceal themselves in the body, it often means that patients with aggressive cancers experience a recurrence of the cancer after treatment. By programming genetically modified killer immune cells to seek and destroy the hiding tumor cells and tumor stem cells, it is hoped that we can develop more effective treatment options. An international research project, wit

https://www.stemcellcenter.lu.se/article/eu-funding-killer-cells-fight-cancer - 2025-12-01